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Norvasc (amlodipine besylate) is a type of drug called a calcium channel blocker used to treat high blood pressure and angina. 5 mg, 5 mg and 10 mg tabletsFDA Approved: NoGeneral Description. This calcium channel blocker lowers blood pressure in part by interfering with the flow of calcium into artery walls. The most common side effects are headache and edema Save up to 80% on your prescriptions. It is what we refer to as the “ LESS THAN 1% ” rate Norvasc therapy has not been associated with clinically significant changes in routine laboratory tests. You may report side effects to Health Canada at 1-866-234-2345 This product information is intended only for residents of the United States. Most side effects are mild or moderate: headache swelling of your legs or ankles tiredness, extreme sleepiness. For Healthcare professionals: NORVASC U. Flushing (warmth, redness, or tingly feeling); swelling in your ankles and lower part of your legs. 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